4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester
CAS: 305834-79-1
Molecular Formula: C17H17ClN2O5
4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester - Names and Identifiers
4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester - Physico-chemical Properties
| Molecular Formula | C17H17ClN2O5 |
| Molar Mass | 364.78 |
| Density | 1.340±0.06 g/cm3(Predicted) |
| Boling Point | 524.8±50.0 °C(Predicted) |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 3.03±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| In vitro study | SC79 inhibits PH AKTM/sub>-GFP plasma membrane translocation and enhances phosphorylation of three Akt subtypes in HEK293,HeLa,HL60,NB4, and HsSulton (B cell) cells. SC79 reduces neuroexcitotoxicity and prevents stroke-induced neuronal death. SC79 restores the proliferation of BRAT1 knockout cells and reduces the production of superoxide in MitoSox positive cells mitochondria. |
| In vivo study | In a permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, I. p.) it can activate Akt in the cytoplasm and reproduce the primary cellular function of Akt signaling, thereby increasing the survival of neurons. |
4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester - Risk and Safety
| WGK Germany | 3 |
4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.741 ml | 13.707 ml | 27.414 ml |
| 5 mM | 0.548 ml | 2.741 ml | 5.483 ml |
| 10 mM | 0.274 ml | 1.371 ml | 2.741 ml |
| 5 mM | 0.055 ml | 0.274 ml | 0.548 ml |
Last Update：2024-01-02 23:10:35
4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester - Reference Information
| Use | 2-amino-6-chloro-ALPHA-cyano -3-(ethoxycarbonyl)-4H-1-benzopyrane-4-ethyl acetate is a chromene compound. The scientific name of chroene (chromene) is benzopyran, which is the basic skeleton of a class of natural organic compounds. Very polychromatic alkene compounds have a wide range of biological activities and photochromic effects, and can be used in the field of molecular recognition. |
| preparation | in a 50mL round bottom flask, add 5-chloro salicylaldehyde 10mmol, ethyl cyanoacetate 25mmol, anhydrous potassium carbonate 1mmol,20mL water as solvent, add a magnetic stirrer, and stop the magnetic stirring reaction after a certain period of time in a constant temperature water bath. Let it stand for cooling, pour out the supernatant, add 15mL of ice-cold volume fraction 95% ethanol to the solid residue, minch the block solid, filter, and wash the solid with a small amount of ice-cold volume fraction 95% ethanol for 2-3 times to obtain a white crystal 2-Amino -6-Chloro-ALPHA-cyano -3-(ethoxycarbonyl)-4H-1-benzopyranopy-4-ethyl acetate, dry, weigh, and calculate the yield, the melting point, IR and HNMR of the product were determined to characterize its structure. IR(KBr),v/cm-1:3419.7,3312.1,2982.5,2938.2,2253.4,1736.2,1685.4,1622.2,1523.3,1479.6,1419.2,1370.2,1289.2,1228.2,1197.5,1092.7,1040.4,826,793.7. |
| biological activity | SC79 is a brain osmotic Akt phosphorylation activator and a Akt-PH domain translocation inhibitor. |
| target | TargetValue Akt |
| Target | Value |
| in vitro study | SC79 inhibits PH AKTM/sub>-GFP plasma membrane translocation and enhances the phosphorylation of three Akt subtypes in HEK293,HeLa,HL60,NB4, and HsSulton (B cells) cells. SC79 reduces neuroexcitatory toxicity and prevents stroke-induced neuronal death. SC79 restores the proliferation of BRAT1 knockout cells and reduces the production of superoxide in mitochondria of MitoSox positive cells. |
| in vivo study | in a mouse model of permanent local cerebral ischemia, SC79 (0.04 mg/g, I. p.) can activate Akt in cytoplasm and reproduce the primary cell function of Akt signal, thus increasing the survival of neurons. |
Last Update：2024-04-09 01:59:58
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Spot supply
Product Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester Visit Supplier Webpage Request for quotationCAS: 305834-79-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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